After a young housewife murders her family in her own house, a single mother and young detective tries to investigate and solve the case. Later, she discovers the house is cursed by a vengeful ghost that dooms those who enter it with a violent death. Now, she runs to save herself and her son from demonic spirits from the cursed house in her neighborhood.
The original plan was to reboot the series completely, featuring a new storyline that abandons the Saeki family. However, it was confirmed in an interview with Nicholas Pesce that the film takes place during the events of The Grudge (2004) and The Grudge 2 (2006).